EXOMIND & rTMS Research Library
A meta-analysis of randomized, double-blind, sham-controlled studies found that adjunctive rTMS improved response and remission outcomes for adults with major depression after two treatment failures.
Why this finding matters
When depression has not improved after more than one treatment, people often need a different approach rather than another version of the same plan. In this analysis, response and remission were meaningfully more common with active rTMS than with sham treatment, a strong reason to discuss whether non-invasive brain stimulation belongs in an individualized treatment plan.
Research Spotlight
2.25× more likely to respond
- 39.7% active-rTMS response
- 13.7% sham response
- 35.7% active-rTMS remission
- 8.4% sham remission
What the evidence suggests
Nineteen trials involving 854 participants contributed to the response analysis, and nine trials involving 551 participants contributed to the remission analysis. The pooled risk ratios were 2.25 for response and 2.78 for remission compared with sham stimulation.
What this could mean for you
This evidence supports discussing rTMS as a non-invasive treatment option when depression has not improved adequately with standard care. At Calgary Mind & Wellness Clinic, EXOMIND suitability is determined through clinical screening rather than from diagnosis alone.
A careful, individualized next step
Research informs—but does not replace—individual clinical judgment. We review symptoms, diagnosis, previous treatment, medications, contraindications, functional goals and the strength of evidence for the proposed protocol. A consultation does not guarantee that treatment will be recommended.
Could EXOMIND be a reasonable next step?
A consultation is an opportunity to review previous treatments, current symptoms, medications, safety considerations and goals. It is not a commitment to purchase a package.
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Study citation
Vida et al. Efficacy of repetitive transcranial magnetic stimulation in treatment-resistant depression: a meta-analysis of randomized sham-controlled trials. PMID: 37501135 · DOI: 10.1016/j.psychres.2023.115396.
View the original record on PubMed
Educational information only. Findings from pooled research do not predict individual outcomes and may involve devices or protocols that differ from EXOMIND.